COVID-19 Miniseries Episode 35: Alternative Ventilation Strategies

This episode was recorded on May 12, 2020.Guest: James E. Baker, R.R.T., L.R.T. & Steven R. Holets, R.R.T., L.R.T.Host: Amit K. Ghosh, M.D., M.B.A. (@AmitGhosh006)What are some alternative ventilation strategies we can use to treat patients with COVID-19? James Baker, R.R.T., L.R.T. and Steve Holets, R.R.T., L.R.T. discuss individualizing care, limitations based on device design, and supply chain concerns.AskMayoExpert COVID-19 Resources: https://askmayoexpert.mayoclinic.org/navigator/COVID-19Connect with the Mayo Clinic’s School of Continuous Professional Developmentonline at https://ce.mayo.edu/oron Twitter @MayoMedEd.

COVID-19 Miniseries Episode 34: Multi-System Inflammatory Syndrome (MIS-C) in Pediatric Patients

This episode was recorded on May 27, 2020.Guest: Nipunie S. Rajapakse, M.D., M.P.H. (@nrajapakseMD)Host: Amit K. Ghosh, M.D., M.B.A. (@AmitGhosh006)Patients under 21 who present with fever, lab evidence of inflammation, multisystem involvement, and recent or current SARS-CoV-2 infection fall under the case definition for multisystem inflammatory syndrome. They commonly present with persistent fever and gastrointestinal symptoms and concerningly, shock. Why are we seeing disproportionate rates in children of racial and ethnic minorities? Dr. Nipunie Rajapaske concisely covers what’s known about this syndrome and the data supporting its emergence as a post-infection complication.CDC Health Advisory on Multisystem Inflammatory Syndrome in Children (MIS-C)https://emergency.cdc.gov/han/2020/han00432.aspAn outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort studyhttps://doi.org/10.1016/S0140-6736(20)31103-XAskMayoExpert COVID-19 Resources: https://askmayoexpert.mayoclinic.org/navigator/COVID-19Connect with the Mayo Clinic’s School of Continuous Professional Developmentonline at https://ce.mayo.edu/oron Twitter @MayoMedEd.

COVID-19 Miniseries Episode 33: Mayo Clinic Q&A - COVID-19 Transmission Risks and Precautions

This episode is shared from Mayo Clinic Q&A and was recorded on May 26, 2020.Guest: Gregory A. Poland, M.D. (@drgregpoland)Host: Halena M. Gazelka, M.D. (@hmgazelkamd)According to the Centers for Disease Control and Prevention, the most common mode of transmission for COVID-19 is through close contact from person to person. While it is possible that someone can get COVID-19 by touching a surface or object that has the virus on it and then touching their own mouth, nose or possibly their eyes, this isn’t thought to be the main way the virus spreads.On the Mayo Clinic Q&A podcast, Dr. Gregory Poland, an infectious diseases expert and head of Mayo Clinic’s Vaccine Research Group, discusses virus transmission and steps to take to keep yourself safe.AskMayoExpert COVID-19 Resources: https://askmayoexpert.mayoclinic.org/navigator/COVID-19Connect with the Mayo Clinic’s School of Continuous Professional Developmentonline at https://ce.mayo.edu/oron Twitter @MayoMedEd.

COVID-19 Miniseries Episode 32: The Fierce Urgency of Now - Pursuing a Safe and Efficacious Vaccine

This episode was recorded May 22, 2020To claim credit visit: https://ce.mayo.edu/covid19podcastGuest: Gregory A. Poland, M.D. (@drgregpoland)Host: Amit K. Ghosh, M.D., M.B.A. (@AmitGhosh006)SARS-CoV-2, as an RNA virus, has marked capacity for mutation and recombination events. How do we build an efficacious and safe vaccine against it? How could we safely speed up development? Is a vaccine neutralizing the spike protein enough? Dr. Greg Poland returns to give you an update from the front lines of research on vaccine development and ongoing clinical trials.Dr. Poland’s Editorial:Tortoises, hares, and vaccines: A cautionary note for SARS-CoV-2 vaccine developmenthttps://doi.org/10.1016/j.vaccine.2020.04.073'I Have A Dream' Speech, In Its Entiretyhttps://www.npr.org/2010/01/18/122701268/i-have-a-dream-speech-in-its-entiretyOur 'Fierce Urgency of Now' - Secretary Kathleen Sebeliushttps://obamawhitehouse.archives.gov/blog/2013/08/26/our-fierce-urgency-nowKing Legacy: 'Fierce Urgency of Now' Exists Today - Terri Moon Cronkhttps://www.defense.gov/Explore/Features/Story/Article/2059480/king-legacy-fierce-urgency-of-now-exists-today/AskMayoExpert COVID-19 Resources: https://askmayoexpert.mayoclinic.org/navigator/COVID-19Connect with the Mayo Clinic’s School of Continuous Professional Developmentonline at https://ce.mayo.edu/oron Twitter @MayoMedEd.

COVID-19 Miniseries Episode 31: The Safety of Convalescent Plasma

This episode was recorded May 21, 2020Visit the program site here: https://www.uscovidplasma.orgTo claim credit visit: https://ce.mayo.edu/covid19podcastGuest: Michael J. Joyner, M.D. (@DrMJoyner)Host: Amit K. Ghosh, M.D., M.B.A. (@AmitGhosh006)Convalescent plasma as a passive immunity strategy is not new. What nuances apply for it’s application to treating COVID-19? Is it safe? Is it efficacious? Dr. Michael Joyner, Principal Investigator for Expanded Access to Convalescent Plasma for the Treatment of Patients with COVID-19, discusses what’s known about this treatment option, information that’s currently being gathered, and how you can get involved.AABB Coronavirus Resources: http://www.aabb.org/advocacy/regulatorygovernment/Pages/AABB-Coronavirus-Resources.aspxAskMayoExpert COVID-19 Resources: https://askmayoexpert.mayoclinic.org/navigator/COVID-19Connect with the Mayo Clinic’s School of Continuous Professional Developmentonline at https://ce.mayo.edu/oron Twitter @MayoMedEd.

COVID-19 Miniseries Episode 30: Mayo Clinic Q&A - Addressing Health Disparities Amplified by COVID-19

This episode is shared from Mayo Clinic Q&A and was recorded in May 2020.Guest: Irene G. Sia, M.D.; Mark L. Wieland, M.D.Host: Sanjeev (Sanj) Kakar, M.D. (@sanjkakar)Minorities are being affected disproportionately by the COVID-19 pandemic. Early data shows that African Americans and other U.S. ethnic minorities have contracted COVID-19 at a higher rate and experience greater sickness and a higher death rate than other Americans.On the Mayo Clinic Q&A podcast, Dr. Irene Sia, a Mayo Clinic infectious diseases expert, and Dr. Mark Wieland, a Mayo Clinic community internal medicine physician, discuss ethnic disparities and COVID-19, including research being done with the Rochester Healthy Community Partnership.AskMayoExpert COVID-19 Resources: https://askmayoexpert.mayoclinic.org/navigator/COVID-19Connect with the Mayo Clinic’s School of Continuous Professional Developmentonline at https://ce.mayo.edu/oron Twitter @MayoMedEd.

COVID-19 Miniseries Episode 29: Lab Medicine Rounds - Understanding COVID-Associated Coagulopathy

This episode is shared from Lab Medicine Rounds and was recorded May 1, 2020.To claim credit visit: https://ce.mayo.edu/covid19podcastGuest:Ariela L. Marshall, M.D. (@AMarshallMD)Host: Justin D. Kreuter, M.D. (@KreuterMD)What is COVID-Associated coagulopathy? Why is it so important to recognize early on? How does it differ from the typical disseminated intravascular coagulation (DIC) picture? Dr. Ariela Marshall details the lab patterns, implications for our patients, and what testing should be evaluated on patients being treated for COVID-19 and when.Time Stamps:00:00 Podcast Intro00:40 What is COVID-associated coagulopathy and why is it important to recognize this?02:45 How is this coagulopathy similar to or different from other coagulopathies that we commonly see in clinical practice?04:30 Is there recommended testing for COVID-associated coagulopathy?06:30 Can you explain what the soluble fibrin monomer test is?08:09 How is COVID-associated coagulopathy managed in terms of prophylactic anticoagulation, therapeutic anticoagulation, and prophylactic transfusion?14:23 What are a few lessons that you have learned during this pandemic so far?Resources: F.A. Klok, M.J.H.A. Kruip, N.J.M. van der Meer, et al., Incidence of thrombotic complications in critically ill ICU patients with COVID-19,Thrombosis Research (2020) https://doi.org/10.1016/j.thromres.2020.04.013 Thachil J, Tang N, Gando S, Falanga A, Cattaneo M...Iba T, et al. ISTH interim guidance on recognition and management of coagulopathy in COVID‐19 https://doi.org/10.1111/jth.14810AskMayoExpert COVID-19 Resources: https://askmayoexpert.mayoclinic.org/navigator/COVID-19ISTH COVID-19 ResourcesSubscribe to Lab Medicine Rounds here: https://news.mayocliniclabs.com/podcast/lab-medicine-rounds/Connect with the Mayo Clinic’s School of Continuous Professional Developmentonline at https://ce.mayo.edu/oron Twitter @MayoMedEd.

COVID-19 Miniseries Episode 28: Reflections on Telehealth and Teaching

This episode was recorded April 30, 2020.To claim credit visit: https://ce.mayo.edu/covid19podcastGuest: Christopher A. Aakre, M.D.Host: Amit K. Ghosh, M.D., M.B.A. (@AmitGhosh006)How do you approach planning for telehealth visits? Dr. Chris Aakre discusses preparing by considering How am I going to assess this concern by video? What are you looking for? What are you hoping to see there? How are you best going to be able to instruct the patient?AskMayoExpert COVID-19 Resources: https://askmayoexpert.mayoclinic.org/navigator/COVID-19Connect with the Mayo Clinic’s School of Continuous Professional Developmentonline at https://ce.mayo.edu/oron Twitter @MayoMedEd.

COVID-19 Miniseries Episode 27: Safely Individualizing the Approach to Treatment for COVID-19

This episode was recorded in May 6, 2020Claim credit here: https://ce.mayo.edu/covid19podcastGuest: Alice Gallo De Moraes, M.D.Host: Amit K. Ghosh, M.D., M.B.A. (@AmitGhosh006)Patients hospitalized with COVID-19 are presenting with and developing severe lung injury, thrombosis, heart injury, and renal insufficiency. What is the observed rate of ventilation? Dr. Alice Gallo De Moraes discusses an individualized approach to intubation for critical support of patients infected with SARS-CoV-2.AskMayoExpert COVID-19 Resources: https://askmayoexpert.mayoclinic.org/navigator/COVID-19Connect with the Mayo Clinic’s School of Continuous Professional Developmentonline at https://ce.mayo.edu/oron Twitter @MayoMedEd.

COVID-19 Miniseries Episode 26: Mayo Clinic Q&A - Atypical Kawasaki Disease, Recombination Events, and Antiviral Therapy Updates

This episode is shared from Mayo Clinic Q&A and was recorded in May 2020.To claim credit visit https://ce.mayo.edu/covid19podcastGuest: Gregory Poland, M.D. (@drgregpoland)Host: Halena M. Gazelka, M.D. (@hmgazelkamd)On the Mayo Clinic Q&A podcast, Dr. Gregory Poland, an infectious diseases expert and head of Mayo Clinic’s Vaccine Research Group, discusses how SARS-CoV-2 is mutating, atypical Kawasaki disease emerging in pediatric patients, updates in antiviral therapies and how scientists and researchers are rapidly gaining new knowledge about the virus and the disease that it causes.AskMayoExpert COVID-19 Resources: https://askmayoexpert.mayoclinic.org/navigator/COVID-19Connect with the Mayo Clinic’s School of Continuous Professional Developmentonline at https://ce.mayo.edu/oron Twitter @MayoMedEd.