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FoundMyFitness

Rhonda Patrick, Ph.D.

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FoundMyFitness

FoundMyFitness

Rhonda Patrick, Ph.D.

789
Followers
3.5K
Plays
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About Us

Promoting strategies to increase healthspan, well-being, cognitive and physical performance through deeper understandings of biology.

Latest Episodes

COVID-19 Q&A #2 - Antibody-Dependent Enhancement, Cross-Immunity, Immunity Duration & More

This is a continuation of the last episode where Dr. Patrick took questions from newsletter subscribers around the on-going pandemic and tried to add value by talking about some of the recent research, among other things. Some of the topics that came up as a result of the questions submitted include: 00:04:03 - Data surrounding SARS-CoV-2 duration 00:06:37 - SARS-CoV-2 and potential immunity 00:11:35 - Some of the main factors known to play a role in immune variation 00:12:05 - What role genetics may play in immune function 00:14:27 - How previous viral exposure regulates immunity 00:15:05 - What cross immunity is and how it may be relevant for SARS-CoV-2 00:19:46 - Antibody-dependent enhancement and SARS-CoV-2 relevance 00:21:50 - How sleep is a key regulator of immune function 00:23:44 - Microbiome composition and immune function 00:28:31 - The differential effects of exercise intensity and duration on immune regulation 00:35:00 - How specific micronutrient inadequacies may promote immune dysregulation 00:47:20 - The effect of sex hormones on immune function 00:48:55 - How biological age age may play a role in immune regulation 00:49:46 - Controversy surrounding hypertension drugs such as ACE inhibitors and COVID-19 00:53:15 - ARDS and long-term lung damage Get our detailed summary, timeline, references and more on the FoundMyFitness episode page. This episode mentions a number of genetic polymorphisms that affect viral entry into the host cell, viral replication, host immune response ranging from cytokine production to viral-induced inflammation, SNPs that affect vitamin D levels and more. If you have used any consumer-based genetic testing services like 23andMe or Ancestry DNA we have a free viral report with these SNPs that you can check out. Learn more about this free report by clicking here. If you enjoy this content or any of the associated content, I can promise you that not only does the premium membership help bring MORE of it into the world in a broadly accessible format, that membership also comes with some really great benefits just for members. Members enjoy extra science emails twice per month, my monthly Question & Answer sessions, and a whole lot more. Support the show and get cool perks, that's the bottom line. Click here to learn more about premium membership.

55 MINJUN 11
Comments
COVID-19 Q&A #2 - Antibody-Dependent Enhancement, Cross-Immunity, Immunity Duration & More

Vitamin C: Oral vs. Intravenous, Immune Effects, Cancer, Exercise Adaptation & More

In this episode, Dr. Rhonda Patrick discuss all things vitamin C. This episode covers oral bioavailability, intravenous vitamin C bioavailability, immune cell function, common cold and other viral infections, lung function, sepsis, pneumonia, inflammation, intravenous vitamin C and cancer, role in exercise, safety concerns, and so, so much more! Episode Timeline (abridged) 00:07:33 - Background on vitamin C 00:17:09 - Bioavailability of vitamin C [including dosing frequency] 00:22:53 - Vitamin C in the context of the common cold 00:28:09 - Vitamin C and lung function 00:35:54 - Vitamin C in the context of exercise [includes discussion of blunting of exercise adaptation] 00:45:51 - Vitamin C and fatty acid oxidation, including relevance in obesity 00:48:44 - Vitamin C and the brain 00:51:15 - Intravenous Vitamin C and its use for the treatment of certain kinds of infection 00:55:33 - Intravenous Vitamin C and cancer 00:57:40 - Effect of Vitamin C on fertility and reproduction 00:58:3...

79 MINMAY 13
Comments
Vitamin C: Oral vs. Intravenous, Immune Effects, Cancer, Exercise Adaptation & More

COVID-19 Q&A #1 with Rhonda Patrick, Ph.D.

This episode features Dr. Rhonda Patrick answering some of the most popular questions related to COVID-19. Look for another COVID-19-focused Q&A, coming soon. Some of the questions we selected from the batch to cover in this episode include: 00:02:36 - Are children and infants susceptible to COVID-19? Are some more susceptible to a more severe form of the disease? Are they carriers of it and possibly spreading transmission? 00:11:00 - Can you explain a little about hydroxychloroquine as possibly treating COVID-19? How does it work? Does it have to do with it being a zinc ionophore? 00:17:58 - Can you talk about quercetin's role as a zinc ionophore? 00:20:51 - Is there any indication blood type influences COVID-19 risk? 00:24:52 - Would you shed light on the conversation regarding vitamin D upregulating ACE2 receptors and vitamin D's influence on susceptibility to COVID19 infection? 00:43:45 - Can you discuss whether sauna use might help prevent COVID19? 00:52:55 - Is it true that hi...

74 MINAPR 15
Comments
COVID-19 Q&A #1 with Rhonda Patrick, Ph.D.

New Omega-3, sulforaphane research, and more! [Kevin Rose Show]

This episode was originally recorded for The Kevin Rose Show. Given some of the unique discussions we had, I had no choice but to ask the great Kevin Rose if he would let me re-post it over here on the FoundMyFitness podcast feed. A request which he graciously obliged. In this episode, we discuss... 00:08:00 - Omega-3 00:27:23 - Metformin 00:50:05 - Sulforaphane 01:06:57 - Magnesium L-Threonate 01:13:44 - Sauna 01:23:48 - New FMF Membership Learn more about the new premium membership. Learn more about sauna on our overview page. Learn more about metformin on our overview page. Learn more about Kevin Rose at his website or on his Twitter @kevinrose. You can also subscribe to either of his two podcasts: Kevin Rose Show Foundation by True Ventures

96 MINJAN 7
Comments
New Omega-3, sulforaphane research, and more! [Kevin Rose Show]

Is Resveratrol a Longevity Compound?

In this episode, Rhonda gives a summary of the science of resveratrol including its effects in animals and humans, mechanisms, and the bottom line on resveratrol supplementation and safety. Learn more about resveratrol at our comprehensive overview Relevant timepoints... 00:03:39 - Clinical effects of resveratrol in humans 00:04:10 - Effects on cardiovascular health biomarkers in humans 00:06:54 - Reduction of inflammatory biomarkers in humans 00:08:11 - Improved cognition and memory in clinical studies 00:11:23 - Healthspan improvements in animals 00:12:28 - Induction of longevity genes via xenohormesis 00:16:19 - Contradictory effects on exercise-associated benefits 00:20:34 - Various factors that affect resveratrol bioavailability 00:23:09 - Unintentional effects on drug metabolism Get earlier access with the premium members early access podcast feed, monthly Q&A sessions, an exclusive bi-weekly science digest email, and more! Click here to learn about premium. Click here to sign...

28 MIN2019 DEC 31
Comments
Is Resveratrol a Longevity Compound?

NAD+, Nicotinamide Riboside, and Nicotinamide Mononucleotide with Rhonda Patrick

In this episode, Rhonda describes NAD+ (perhaps one of the most important molecules in the human body), why it is so important for aging, and why it declines with age. She discusses some of the popular NAD+ boosters like nicotinamide riboside and nicotinamide mononucleotide, explains what the animal and human data say, discusses some of the concerns associated with using these boosters, and provides some concluding thoughts. Learn more about NAD+ Learn more about nicotinamide riboside Learn more about nicotinamide mononucleotide Learn more about sirtuins Get earlier access with the premium members early access podcast feed, monthly Q&A sessions, an exclusive bi-weekly science digest email, and more! Click here to get started.

35 MIN2019 NOV 14
Comments
NAD+, Nicotinamide Riboside, and Nicotinamide Mononucleotide with Rhonda Patrick

Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More

David A. Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. He is the co-founder of the journal Aging, where he serves as co-chief editor. Dr. Sinclair's work focuses on understanding the mechanisms that drive human aging and identifying ways to slow or reverse aging's effects. In particular, he has examined the role of sirtuins in disease and aging, with special emphasis on how sirtuin activity is modulated by compounds produced by the body as well as those consumed in the diet, such as resveratrol. His work has implications for human metabolism, mitochondrial and neurological health, and cancer. In this episode, we discuss... 00:17:59 - How caloric restriction, fasting, and exercise increase levels of a molecule called NAD+ and how this activates sirtuins, a family of genes involved in longevity. 00:21:47 - How NAD+ levels and sirtuin activities decrease with age,...

82 MIN2019 NOV 7
Comments
Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More

Sauna Use as an Exercise Mimetic for Heart and Healthspan

This podcast is the audio from a presentation Dr. Rhonda Patrick gave on how the sauna may be an exercise mimetic for heat health and healthspan. Sauna use has emerged as a means to increase lifespan and improve overall health, based on compelling data from observational, interventional, and mechanistic studies. Listen in to find out more. Click here to get the episode show notes and video. Watch the episode with cardiologist and sauna scientist Dr. Jari Laukkanen. Did you enjoy this podcast? It was brought to you by people like you! Click here to visit our crowdsponsor page where you can learn more about how to support the podcast.

46 MIN2019 SEP 16
Comments
Sauna Use as an Exercise Mimetic for Heart and Healthspan

Exercise as a Treatment for Depression

In this short episode, Dr. Patrick discusses some of the compelling science including observational studies, randomized controlled trials, and human mechanistic studies that suggests exercise is a powerful tool for preventing or managing the symptoms of depression and mental illness. Moreover, she talks about the specific types of exercise and exercise parameters that evidence suggests might be the most helpful for depression. This podcast started its life as a video, so make sure to check out the full video or the references and episode notes on the episode page. Click here to get this episode's show notes and video. Click here to visit the in-depth depression topic page. See the full interview with Dr. Charles Raison. Did you enjoy this podcast? It was brought to you by people like you! Click here to visit our crowdsponsor page where you can learn more about how to support the podcast and access the premium members benefits.

17 MIN2019 AUG 3
Comments
Exercise as a Treatment for Depression

Dr. Elissa Epel on Telomeres and the Role of Stress Biology in Cellular Aging

Elissa Epel, PhD, is a Professor in the Department of Psychiatry at the University of California, San Francisco where she serves as the director of the Aging, Metabolism, and Emotions Center. Her research centers on the mechanisms of healthy aging and the associations between stress, telomere length, addiction, eating, and metabolic health. In this episode, we dive deep into the world of telomeres, the length of which is one of the useful biomarkers scientists have for getting a sense of the differences between how individuals or groups of individuals age. Telomere shortening is both a cause and a symptom of aging and plays key roles in not only how long we live, but in how well. Lifestyle factors such as poor nutrition and smoking can accelerate telomere shortening by generating oxidative stress and inflammation. Click here to get this episode's show notes and transcript. Watch this episode's highlights on the FMF Clips channel. Did you enjoy this podcast? It was brought to you by ...

73 MIN2019 JUN 10
Comments
Dr. Elissa Epel on Telomeres and the Role of Stress Biology in Cellular Aging

Latest Episodes

COVID-19 Q&A #2 - Antibody-Dependent Enhancement, Cross-Immunity, Immunity Duration & More

This is a continuation of the last episode where Dr. Patrick took questions from newsletter subscribers around the on-going pandemic and tried to add value by talking about some of the recent research, among other things. Some of the topics that came up as a result of the questions submitted include: 00:04:03 - Data surrounding SARS-CoV-2 duration 00:06:37 - SARS-CoV-2 and potential immunity 00:11:35 - Some of the main factors known to play a role in immune variation 00:12:05 - What role genetics may play in immune function 00:14:27 - How previous viral exposure regulates immunity 00:15:05 - What cross immunity is and how it may be relevant for SARS-CoV-2 00:19:46 - Antibody-dependent enhancement and SARS-CoV-2 relevance 00:21:50 - How sleep is a key regulator of immune function 00:23:44 - Microbiome composition and immune function 00:28:31 - The differential effects of exercise intensity and duration on immune regulation 00:35:00 - How specific micronutrient inadequacies may promote immune dysregulation 00:47:20 - The effect of sex hormones on immune function 00:48:55 - How biological age age may play a role in immune regulation 00:49:46 - Controversy surrounding hypertension drugs such as ACE inhibitors and COVID-19 00:53:15 - ARDS and long-term lung damage Get our detailed summary, timeline, references and more on the FoundMyFitness episode page. This episode mentions a number of genetic polymorphisms that affect viral entry into the host cell, viral replication, host immune response ranging from cytokine production to viral-induced inflammation, SNPs that affect vitamin D levels and more. If you have used any consumer-based genetic testing services like 23andMe or Ancestry DNA we have a free viral report with these SNPs that you can check out. Learn more about this free report by clicking here. If you enjoy this content or any of the associated content, I can promise you that not only does the premium membership help bring MORE of it into the world in a broadly accessible format, that membership also comes with some really great benefits just for members. Members enjoy extra science emails twice per month, my monthly Question & Answer sessions, and a whole lot more. Support the show and get cool perks, that's the bottom line. Click here to learn more about premium membership.

55 MINJUN 11
Comments
COVID-19 Q&A #2 - Antibody-Dependent Enhancement, Cross-Immunity, Immunity Duration & More

Vitamin C: Oral vs. Intravenous, Immune Effects, Cancer, Exercise Adaptation & More

In this episode, Dr. Rhonda Patrick discuss all things vitamin C. This episode covers oral bioavailability, intravenous vitamin C bioavailability, immune cell function, common cold and other viral infections, lung function, sepsis, pneumonia, inflammation, intravenous vitamin C and cancer, role in exercise, safety concerns, and so, so much more! Episode Timeline (abridged) 00:07:33 - Background on vitamin C 00:17:09 - Bioavailability of vitamin C [including dosing frequency] 00:22:53 - Vitamin C in the context of the common cold 00:28:09 - Vitamin C and lung function 00:35:54 - Vitamin C in the context of exercise [includes discussion of blunting of exercise adaptation] 00:45:51 - Vitamin C and fatty acid oxidation, including relevance in obesity 00:48:44 - Vitamin C and the brain 00:51:15 - Intravenous Vitamin C and its use for the treatment of certain kinds of infection 00:55:33 - Intravenous Vitamin C and cancer 00:57:40 - Effect of Vitamin C on fertility and reproduction 00:58:3...

79 MINMAY 13
Comments
Vitamin C: Oral vs. Intravenous, Immune Effects, Cancer, Exercise Adaptation & More

COVID-19 Q&A #1 with Rhonda Patrick, Ph.D.

This episode features Dr. Rhonda Patrick answering some of the most popular questions related to COVID-19. Look for another COVID-19-focused Q&A, coming soon. Some of the questions we selected from the batch to cover in this episode include: 00:02:36 - Are children and infants susceptible to COVID-19? Are some more susceptible to a more severe form of the disease? Are they carriers of it and possibly spreading transmission? 00:11:00 - Can you explain a little about hydroxychloroquine as possibly treating COVID-19? How does it work? Does it have to do with it being a zinc ionophore? 00:17:58 - Can you talk about quercetin's role as a zinc ionophore? 00:20:51 - Is there any indication blood type influences COVID-19 risk? 00:24:52 - Would you shed light on the conversation regarding vitamin D upregulating ACE2 receptors and vitamin D's influence on susceptibility to COVID19 infection? 00:43:45 - Can you discuss whether sauna use might help prevent COVID19? 00:52:55 - Is it true that hi...

74 MINAPR 15
Comments
COVID-19 Q&A #1 with Rhonda Patrick, Ph.D.

New Omega-3, sulforaphane research, and more! [Kevin Rose Show]

This episode was originally recorded for The Kevin Rose Show. Given some of the unique discussions we had, I had no choice but to ask the great Kevin Rose if he would let me re-post it over here on the FoundMyFitness podcast feed. A request which he graciously obliged. In this episode, we discuss... 00:08:00 - Omega-3 00:27:23 - Metformin 00:50:05 - Sulforaphane 01:06:57 - Magnesium L-Threonate 01:13:44 - Sauna 01:23:48 - New FMF Membership Learn more about the new premium membership. Learn more about sauna on our overview page. Learn more about metformin on our overview page. Learn more about Kevin Rose at his website or on his Twitter @kevinrose. You can also subscribe to either of his two podcasts: Kevin Rose Show Foundation by True Ventures

96 MINJAN 7
Comments
New Omega-3, sulforaphane research, and more! [Kevin Rose Show]

Is Resveratrol a Longevity Compound?

In this episode, Rhonda gives a summary of the science of resveratrol including its effects in animals and humans, mechanisms, and the bottom line on resveratrol supplementation and safety. Learn more about resveratrol at our comprehensive overview Relevant timepoints... 00:03:39 - Clinical effects of resveratrol in humans 00:04:10 - Effects on cardiovascular health biomarkers in humans 00:06:54 - Reduction of inflammatory biomarkers in humans 00:08:11 - Improved cognition and memory in clinical studies 00:11:23 - Healthspan improvements in animals 00:12:28 - Induction of longevity genes via xenohormesis 00:16:19 - Contradictory effects on exercise-associated benefits 00:20:34 - Various factors that affect resveratrol bioavailability 00:23:09 - Unintentional effects on drug metabolism Get earlier access with the premium members early access podcast feed, monthly Q&A sessions, an exclusive bi-weekly science digest email, and more! Click here to learn about premium. Click here to sign...

28 MIN2019 DEC 31
Comments
Is Resveratrol a Longevity Compound?

NAD+, Nicotinamide Riboside, and Nicotinamide Mononucleotide with Rhonda Patrick

In this episode, Rhonda describes NAD+ (perhaps one of the most important molecules in the human body), why it is so important for aging, and why it declines with age. She discusses some of the popular NAD+ boosters like nicotinamide riboside and nicotinamide mononucleotide, explains what the animal and human data say, discusses some of the concerns associated with using these boosters, and provides some concluding thoughts. Learn more about NAD+ Learn more about nicotinamide riboside Learn more about nicotinamide mononucleotide Learn more about sirtuins Get earlier access with the premium members early access podcast feed, monthly Q&A sessions, an exclusive bi-weekly science digest email, and more! Click here to get started.

35 MIN2019 NOV 14
Comments
NAD+, Nicotinamide Riboside, and Nicotinamide Mononucleotide with Rhonda Patrick

Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More

David A. Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. He is the co-founder of the journal Aging, where he serves as co-chief editor. Dr. Sinclair's work focuses on understanding the mechanisms that drive human aging and identifying ways to slow or reverse aging's effects. In particular, he has examined the role of sirtuins in disease and aging, with special emphasis on how sirtuin activity is modulated by compounds produced by the body as well as those consumed in the diet, such as resveratrol. His work has implications for human metabolism, mitochondrial and neurological health, and cancer. In this episode, we discuss... 00:17:59 - How caloric restriction, fasting, and exercise increase levels of a molecule called NAD+ and how this activates sirtuins, a family of genes involved in longevity. 00:21:47 - How NAD+ levels and sirtuin activities decrease with age,...

82 MIN2019 NOV 7
Comments
Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More

Sauna Use as an Exercise Mimetic for Heart and Healthspan

This podcast is the audio from a presentation Dr. Rhonda Patrick gave on how the sauna may be an exercise mimetic for heat health and healthspan. Sauna use has emerged as a means to increase lifespan and improve overall health, based on compelling data from observational, interventional, and mechanistic studies. Listen in to find out more. Click here to get the episode show notes and video. Watch the episode with cardiologist and sauna scientist Dr. Jari Laukkanen. Did you enjoy this podcast? It was brought to you by people like you! Click here to visit our crowdsponsor page where you can learn more about how to support the podcast.

46 MIN2019 SEP 16
Comments
Sauna Use as an Exercise Mimetic for Heart and Healthspan

Exercise as a Treatment for Depression

In this short episode, Dr. Patrick discusses some of the compelling science including observational studies, randomized controlled trials, and human mechanistic studies that suggests exercise is a powerful tool for preventing or managing the symptoms of depression and mental illness. Moreover, she talks about the specific types of exercise and exercise parameters that evidence suggests might be the most helpful for depression. This podcast started its life as a video, so make sure to check out the full video or the references and episode notes on the episode page. Click here to get this episode's show notes and video. Click here to visit the in-depth depression topic page. See the full interview with Dr. Charles Raison. Did you enjoy this podcast? It was brought to you by people like you! Click here to visit our crowdsponsor page where you can learn more about how to support the podcast and access the premium members benefits.

17 MIN2019 AUG 3
Comments
Exercise as a Treatment for Depression

Dr. Elissa Epel on Telomeres and the Role of Stress Biology in Cellular Aging

Elissa Epel, PhD, is a Professor in the Department of Psychiatry at the University of California, San Francisco where she serves as the director of the Aging, Metabolism, and Emotions Center. Her research centers on the mechanisms of healthy aging and the associations between stress, telomere length, addiction, eating, and metabolic health. In this episode, we dive deep into the world of telomeres, the length of which is one of the useful biomarkers scientists have for getting a sense of the differences between how individuals or groups of individuals age. Telomere shortening is both a cause and a symptom of aging and plays key roles in not only how long we live, but in how well. Lifestyle factors such as poor nutrition and smoking can accelerate telomere shortening by generating oxidative stress and inflammation. Click here to get this episode's show notes and transcript. Watch this episode's highlights on the FMF Clips channel. Did you enjoy this podcast? It was brought to you by ...

73 MIN2019 JUN 10
Comments
Dr. Elissa Epel on Telomeres and the Role of Stress Biology in Cellular Aging

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