Himalaya: Listen. Learn. Grow.

4.8K Ratings
Open In App
title

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

43
Followers
205
Plays
Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

43
Followers
205
Plays
OVERVIEWEPISODESYOU MAY ALSO LIKE

Details

About Us

A Meded101.com Production

Latest Episodes

Abacavir Pharmacology

Abacavir is a nucleoside reverse transcriptase inhibitor used in the management of HIV. In patients who have the HLA-B*5701 allele, they are at much greater risk for hypersensitivity reactions. Lactic acidosis and hepatomegaly are potential complications with the use of abacavir. While abacavir is not known for a large number of drug interactions, I discuss a few that you have a chance to run into.

13 MIN1 d ago
Comments
Abacavir Pharmacology

Sertraline Pharmacology

Sertraline is an SSRI. It has the highest potential to cause diarrhea of any SSRI. Sertraline is often called "Squirtraline" because of its potential to cause diarrhea. Sertraline has a much shorter half-life than fluoxetine. I discuss why that may be important in this podcast episode. I discuss the role of serotonin in platelet aggregation and how sertraline may affect this.

16 MIN1 w ago
Comments
Sertraline Pharmacology

Fosfomycin Pharmacology

Fosfomycin is an antibacterial agents that can be utilized in the management of uncomplicated UTIs. Uniquely, fosfomycin comes as a packet that needs to be mixed with COOL water. I discuss this further on the podcast. Typhoid and Cholera vaccine effectiveness may be reduced when used with fosfomycin. When there is kidney or systemic infection involvement, it is recommended to avoid the use of fosfomycin.

13 MIN2 w ago
Comments
Fosfomycin Pharmacology

Simvastatin Pharmacology

Simvastatin use has declined over time due to more potent statins being available and due to numerous drug interactions. Grapefruit juice can inhibit CYP3A4 which will increase the concentrations of simvastatin. Genetic variations in SLCO1B1 can lead to patients being more susceptible to simvastatin toxicity. Simvastatin is a lipophilic statin. I discuss why this is important and how it might impact clinical decisions.

15 MIN3 w ago
Comments
Simvastatin Pharmacology

Citalopram Pharmacology

Citalopram is an SSRI used in the management of depression, anxiety, OCD, and PTSD. How do you manage the risk of citalopram causing QTc prolongation? I discuss it further in the podcast. Omeprazole can inhibit CYP2C19 which affects the metabolism of citalopram. I discuss the clinical impacts of this interaction in the podcast. Geriatric dosing with citalopram is recommended to be lower than traditional adult dosing. I discuss this further in the podcast.

17 MINJUL 16
Comments
Citalopram Pharmacology

Epoetin Alfa Pharmacology

Epoetin alfa is essential exogenous erythropoetin which can stimulate the production of red blood cells. It is critical to ensure adequate iron stores when using EPO. Risks for blood clots, strokes and heart attacks are critical to recognize with the use of epoetin. Dosage adjustments with epoetin are typically made with respect to the amount of change in hemoglobin. I discuss this further in the podcast.

14 MINJUL 10
Comments
Epoetin Alfa Pharmacology

Dexamethasone Pharmacology

Dexamethasone has numerous possible indications such as asthma, chemotherapy-induced nausea and vomiting, and pain associated with inflammation. Dexamethasone is more potent than prednisone. Approximately 0.75 mg of dexamethasone is equivalent to 5 mg of prednisone. When using dexamethasone, recall that it can raise blood sugars. Monitor this closely in patients with diabetes. A dexamethasone suppression test helps detect excessive endogenous production of cortisol.

12 MINJUL 2
Comments
Dexamethasone Pharmacology

Sildenafil Pharmacology

On this episode, I discuss sildenafil pharmacology, adverse effects, and important drug interactions. Sildenafil's most common and concerning adverse effect is in relation to its ability to lower blood pressure. I discuss this further in the podcast. Sildenafil can cause rare visual changes that patients should be aware of and report immediately to their pharmacist or physician. The sildenafil nitrate interaction is essential to know. I discuss it in this podcast episode.

13 MINJUN 26
Comments
Sildenafil Pharmacology

Codeine Pharmacology

On this episode, I discuss codeine pharmacology and practical clinical practice pearls. Codeine is metabolized by CYP2D6 to the active metabolite morphine. I discuss how this can be affected by genetics as well as other medications. Constipation is a problem with codeine and all opioids in general. Education and making a plan with patients to combat this side effect is important. Codeine is less potent than other opioids such as fentanyl, hydromorphone, and hydrocodone.

15 MINJUN 19
Comments
Codeine Pharmacology

Dexmedetomidine Pharmacology

Dexmedetomidine is a selective alpha-2-adrenergic agonist with sedative characteristics. Dexmedetomidine is commonly used in ICU and procedural sedation, as well as postoperative pain. A few of the more serious adverse effects of dexmedetomidine to keep an eye on including bradyarrhythmias/bradycardia and hypotension. Dexmedetomidine undergoes hepatic metabolism, meaning a dose reduction may be required in patients with impaired hepatic function. Major drug interactions to monitoring for with dexmedetomidine include co-administration with anesthetics, sedatives, hypnotics, and opioids, as it may lead to an enhancement of effects. It is also important to note that dexmedetomidine may produce withdrawal symptoms if used for longer than 24 hours.

9 MINJUN 11
Comments
Dexmedetomidine Pharmacology

Latest Episodes

Abacavir Pharmacology

Abacavir is a nucleoside reverse transcriptase inhibitor used in the management of HIV. In patients who have the HLA-B*5701 allele, they are at much greater risk for hypersensitivity reactions. Lactic acidosis and hepatomegaly are potential complications with the use of abacavir. While abacavir is not known for a large number of drug interactions, I discuss a few that you have a chance to run into.

13 MIN1 d ago
Comments
Abacavir Pharmacology

Sertraline Pharmacology

Sertraline is an SSRI. It has the highest potential to cause diarrhea of any SSRI. Sertraline is often called "Squirtraline" because of its potential to cause diarrhea. Sertraline has a much shorter half-life than fluoxetine. I discuss why that may be important in this podcast episode. I discuss the role of serotonin in platelet aggregation and how sertraline may affect this.

16 MIN1 w ago
Comments
Sertraline Pharmacology

Fosfomycin Pharmacology

Fosfomycin is an antibacterial agents that can be utilized in the management of uncomplicated UTIs. Uniquely, fosfomycin comes as a packet that needs to be mixed with COOL water. I discuss this further on the podcast. Typhoid and Cholera vaccine effectiveness may be reduced when used with fosfomycin. When there is kidney or systemic infection involvement, it is recommended to avoid the use of fosfomycin.

13 MIN2 w ago
Comments
Fosfomycin Pharmacology

Simvastatin Pharmacology

Simvastatin use has declined over time due to more potent statins being available and due to numerous drug interactions. Grapefruit juice can inhibit CYP3A4 which will increase the concentrations of simvastatin. Genetic variations in SLCO1B1 can lead to patients being more susceptible to simvastatin toxicity. Simvastatin is a lipophilic statin. I discuss why this is important and how it might impact clinical decisions.

15 MIN3 w ago
Comments
Simvastatin Pharmacology

Citalopram Pharmacology

Citalopram is an SSRI used in the management of depression, anxiety, OCD, and PTSD. How do you manage the risk of citalopram causing QTc prolongation? I discuss it further in the podcast. Omeprazole can inhibit CYP2C19 which affects the metabolism of citalopram. I discuss the clinical impacts of this interaction in the podcast. Geriatric dosing with citalopram is recommended to be lower than traditional adult dosing. I discuss this further in the podcast.

17 MINJUL 16
Comments
Citalopram Pharmacology

Epoetin Alfa Pharmacology

Epoetin alfa is essential exogenous erythropoetin which can stimulate the production of red blood cells. It is critical to ensure adequate iron stores when using EPO. Risks for blood clots, strokes and heart attacks are critical to recognize with the use of epoetin. Dosage adjustments with epoetin are typically made with respect to the amount of change in hemoglobin. I discuss this further in the podcast.

14 MINJUL 10
Comments
Epoetin Alfa Pharmacology

Dexamethasone Pharmacology

Dexamethasone has numerous possible indications such as asthma, chemotherapy-induced nausea and vomiting, and pain associated with inflammation. Dexamethasone is more potent than prednisone. Approximately 0.75 mg of dexamethasone is equivalent to 5 mg of prednisone. When using dexamethasone, recall that it can raise blood sugars. Monitor this closely in patients with diabetes. A dexamethasone suppression test helps detect excessive endogenous production of cortisol.

12 MINJUL 2
Comments
Dexamethasone Pharmacology

Sildenafil Pharmacology

On this episode, I discuss sildenafil pharmacology, adverse effects, and important drug interactions. Sildenafil's most common and concerning adverse effect is in relation to its ability to lower blood pressure. I discuss this further in the podcast. Sildenafil can cause rare visual changes that patients should be aware of and report immediately to their pharmacist or physician. The sildenafil nitrate interaction is essential to know. I discuss it in this podcast episode.

13 MINJUN 26
Comments
Sildenafil Pharmacology

Codeine Pharmacology

On this episode, I discuss codeine pharmacology and practical clinical practice pearls. Codeine is metabolized by CYP2D6 to the active metabolite morphine. I discuss how this can be affected by genetics as well as other medications. Constipation is a problem with codeine and all opioids in general. Education and making a plan with patients to combat this side effect is important. Codeine is less potent than other opioids such as fentanyl, hydromorphone, and hydrocodone.

15 MINJUN 19
Comments
Codeine Pharmacology

Dexmedetomidine Pharmacology

Dexmedetomidine is a selective alpha-2-adrenergic agonist with sedative characteristics. Dexmedetomidine is commonly used in ICU and procedural sedation, as well as postoperative pain. A few of the more serious adverse effects of dexmedetomidine to keep an eye on including bradyarrhythmias/bradycardia and hypotension. Dexmedetomidine undergoes hepatic metabolism, meaning a dose reduction may be required in patients with impaired hepatic function. Major drug interactions to monitoring for with dexmedetomidine include co-administration with anesthetics, sedatives, hypnotics, and opioids, as it may lead to an enhancement of effects. It is also important to note that dexmedetomidine may produce withdrawal symptoms if used for longer than 24 hours.

9 MINJUN 11
Comments
Dexmedetomidine Pharmacology
success toast
Welcome to Himalaya LearningDozens of podcourses featuring over 100 experts are waiting for you.